Glomerular Capillary C4d Staining in Native Kidney Biopsies: Associations with Proteinuric Phenotype and Reduced Likelihood of Early Proteinuria Remission
Mehmet Sezen, Melike Nalbant, Suat Akgür, Ayşe Şeker, Nermin Ünal Odabaş, Sibel Bayer, Türker Emre, Mehmet Usta, Yavuz Ayar · 2026
Read Glomerular Capillary C4d Staining in Native Kidney Biopsies: Associations with Proteinuric Phenotype and Reduced Likelihood of Early Proteinuria Remission by Mehmet Sezen, Melike Nalbant, Suat Akgür, Ayşe Şeker, Nermin Ünal Odabaş, Sibel Bayer, Türker Emre, Mehmet Usta, Yavuz Ayar (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13565186.txt.
Description
Mehmet Sezen and co-authors examine what a complement protein stain, C4d, in the kidney's filtering tufts tells about patients with glomerular disease. They reviewed one hundred seventy-three native kidney biopsies stained for the marker. It appeared in about thirty-eight percent, most often in membranous nephropathy and two other conditions.
Patients with positive staining started with heavier protein loss in urine, higher cholesterol, and lower blood albumin. At six months, far fewer of them had brought protein loss under key thresholds. Kidney filtration rates and dialysis need did not differ between groups. Older age and positive staining each independently cut the chance of early remission. The authors call for larger prospective studies before using the stain as a proven prognostic test.
Catalog record
| CREATOR | Mehmet Sezen, Melike Nalbant, Suat Akgür, Ayşe Şeker, Nermin Ünal Odabaş, Sibel Bayer, Türker Emre, Mehmet Usta, Yavuz Ayar |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |