Immunohistochemical Expression of MSH2 and MSH6 Mismatch Repair Proteins and Their Pathological Correlations in Canine Primary Pulmonary Carcinoma
Alexandra Morar, Corina Toma, Dragoș Hodor, Claudiu Gal, Ibrahima Mamadou Sall, Marian Taulescu, Cornel Cătoi · 2026
Read Immunohistochemical Expression of MSH2 and MSH6 Mismatch Repair Proteins and Their Pathological Correlations in Canine Primary Pulmonary Carcinoma by Alexandra Morar, Corina Toma, Dragoș Hodor, Claudiu Gal, Ibrahima Mamadou Sall, Marian Taulescu, Cornel Cătoi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13565168.txt.
Description
Alexandra Morar and six colleagues published a 2026 veterinary study of primary pulmonary carcinoma, lung cancer arising in dogs. The team examined two DNA mismatch repair proteins, MSH2 and MSH6, as possible biomarkers. These proteins fix copying errors in DNA; their loss is a known cancer signal in human oncology but was uncharacterized in canine lung tumors.
The affected dogs had a median age of 10.6 years. Sixteen tumors were adenocarcinomas and one was adenosquamous carcinoma, with papillary architecture the most common pattern. Stains for general epithelial and lung markers were positive in all cases. The researchers then related the repair protein staining to the tumors' pathological features, a first step toward prognostic markers in canine lung cancer.
Catalog record
| CREATOR | Alexandra Morar, Corina Toma, Dragoș Hodor, Claudiu Gal, Ibrahima Mamadou Sall, Marian Taulescu, Cornel Cătoi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |