Modeling Tau-Mediated Pathology in Monkey Brain Slices
Mingtian Pan, Qintian Guo, Peisi Huang, Xiang Han, Sitong Yang, Fengwei Sun, Jiawei Zhang, Laiqiang Chen, Bang Li, Dajian He, Shihua Li, Xiao-Jiang Li, Xiangyu Guo · 2026
Read Modeling Tau-Mediated Pathology in Monkey Brain Slices by Mingtian Pan, Qintian Guo, Peisi Huang, Xiang Han, Sitong Yang, Fengwei Sun, Jiawei Zhang, Laiqiang Chen, Bang Li, Dajian He, Shihua Li, Xiao-Jiang Li, Xiangyu Guo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13564955.txt.
Description
Mingtian Pan and co-authors build a monkey brain slice system to study harmful tau protein, a hallmark of Alzheimer's disease. Rodent tau differs from primate tau, which limits what animal work can show. Slices keep the brain's three-dimensional layout and living networks in the dish.
The team tuned virus delivery to switch on human tau in the slices, with strong uptake in support cells and little harm. Mutant tau built up over a few weeks, with added phosphate marks and clumping. The system works in young and old tissue, and the authors see it as a bridge toward drug testing that is closer to human disease.
Catalog record
| CREATOR | Mingtian Pan, Qintian Guo, Peisi Huang, Xiang Han, Sitong Yang, Fengwei Sun, Jiawei Zhang, Laiqiang Chen, Bang Li, Dajian He, Shihua Li, Xiao-Jiang Li, Xiangyu Guo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |