Ribonucleotide Reductase Inhibition Triggers Ferroptosis in Genetically Defined Subsets of Non–Small Cell Lung Cancer
Utsav Sen, Dalia Natour, Subhamoy Chakraborty, Elisa Gobbini, Chih-wei Fan, Calvin Koelbel, Andrew Elliott, Ari M. Vanderwalde, Hossein Borghaei, Balazs Halmos, Deniz Demircioglu, Dan Hasson, Nishant Gandhi, Triparna Sen · 2026
Read Ribonucleotide Reductase Inhibition Triggers Ferroptosis in Genetically Defined Subsets of Non–Small Cell Lung Cancer by Utsav Sen, Dalia Natour, Subhamoy Chakraborty, Elisa Gobbini, Chih-wei Fan, Calvin Koelbel, Andrew Elliott, Ari M. Vanderwalde, Hossein Borghaei, Balazs Halmos, Deniz Demircioglu, Dan Hasson, Nishant Gandhi, Triparna Sen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13564884.txt.
Description
Utsav Sen and co-authors trigger a rust-like cell death in lung cancer in this 2026 study. Non-small cell lung cancer kills more people than any other cancer type. A key enzyme, ribonucleotide reductase, feeds DNA building and runs hot in many tumors.
Blocking that enzyme, the team found, sets off ferroptosis, a death driven by iron and fat damage. The effect held in gene-defined subsets of the cancer, not all of them. Their hunt drew on gene data from over 27,000 real-world tumors. Resistance to targeted drugs is the backdrop. A fresh death route, opened by an old enzyme, offers a new angle of attack.
Catalog record
| CREATOR | Utsav Sen, Dalia Natour, Subhamoy Chakraborty, Elisa Gobbini, Chih-wei Fan, Calvin Koelbel, Andrew Elliott, Ari M. Vanderwalde, Hossein Borghaei, Balazs Halmos, Deniz Demircioglu, Dan Hasson, Nishant Gandhi, Triparna Sen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |