Widespread atypical UV-induced mutations form in single-stranded DNA
Cameron Cordero, Brittany N. Vandenberg, Isabelle Mittelstadt, Jordan Murch, Marian F. Laughery, Piotr A. Mieczkowski, John J. Wyrick, Steven A. Roberts · 2026
Read Widespread atypical UV-induced mutations form in single-stranded DNA by Cameron Cordero, Brittany N. Vandenberg, Isabelle Mittelstadt, Jordan Murch, Marian F. Laughery, Piotr A. Mieczkowski, John J. Wyrick, Steven A. Roberts (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13564860.txt.
Description
Cameron Cordero and seven co-authors studied how sunlight damages DNA in a 2026 paper. Ultraviolet light leaves marks on DNA that often turn into one well known pattern of mutation, seen in many cancers. Yet some skin cancer mutations do not fit that pattern. The team used yeast to hunt for other kinds of light damage.
The researchers exposed single strands of yeast DNA to repeated doses of ultraviolet light, then read the full genome. They found a wide set of unusual mutations that do not match the classic pattern. The changes resist being undone by light, which points to rare forms of damage as their source. The work also shows how one repair protein handles the classic damage. These findings may help explain odd mutations found in skin cancers such as melanoma.
Catalog record
| CREATOR | Cameron Cordero, Brittany N. Vandenberg, Isabelle Mittelstadt, Jordan Murch, Marian F. Laughery, Piotr A. Mieczkowski, John J. Wyrick, Steven A. Roberts |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |