Deconstructing the Alternative Lengthening of Telomeres: Integromics Prioritizes Five Master Hubs Dictating Clinical Survival and Therapeutic Vulnerabilities
Isaac Armendáriz-Castillo, Santiago Guerrero, Andrés Herrera-Yela, Jhommara Bautista, Andrés López-Cortés · 2026
Read Deconstructing the Alternative Lengthening of Telomeres: Integromics Prioritizes Five Master Hubs Dictating Clinical Survival and Therapeutic Vulnerabilities by Isaac Armendáriz-Castillo, Santiago Guerrero, Andrés Herrera-Yela, Jhommara Bautista, Andrés López-Cortés (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13564831.txt.
Description
Some cancers keep growing by lengthening the caps on their chromosomes through a backup route called ALT. Isaac Armendáriz-Castillo and co-authors map that route in a 2026 study of sarcomas and brain tumors. Older tests looked for two gene faults, but the authors argue that the real picture is a wider shift in gene activity.
The team built a signature from 28 genes that marks the ALT state and tested it on tumor data. The signature predicted shorter survival better than the older gene fault tests. Many of the genes cluster on one chromosome, which may help them switch on together. Network analysis then flagged five hub genes as core drivers, which could guide new drug targets.
Catalog record
| CREATOR | Isaac Armendáriz-Castillo, Santiago Guerrero, Andrés Herrera-Yela, Jhommara Bautista, Andrés López-Cortés |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |