Mechanisms Underlying Negative p53 Immunocytochemistry in Oral Cytology: TP53 mRNA Expression and Sampling Limitations
Takayuki Miyakawa, Satoshi Maruyama, Manabu Yamazaki, Tatsuya Abé, Shigehiro Ono, Kei Tomihara, Jun-ichi Tanuma · 2026
Read Mechanisms Underlying Negative p53 Immunocytochemistry in Oral Cytology: TP53 mRNA Expression and Sampling Limitations by Takayuki Miyakawa, Satoshi Maruyama, Manabu Yamazaki, Tatsuya Abé, Shigehiro Ono, Kei Tomihara, Jun-ichi Tanuma (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13564654.txt.
Description
Takayuki Miyakawa leads a team on why a mouth test can miss a gene mark. Their study from twenty twenty-six deals with p53 in mouth cell tests. The mark should flag high risk mouth sores.
The team sorted a large set of mouth cell samples by class. They ran the stain test and also measured gene message levels. Stain results did not always match the message levels. Sample limits may explain why some tests read as negative. High grade sores and mouth cancers were the focus groups. A firm mark for early finds is still needed.
Catalog record
| CREATOR | Takayuki Miyakawa, Satoshi Maruyama, Manabu Yamazaki, Tatsuya Abé, Shigehiro Ono, Kei Tomihara, Jun-ichi Tanuma |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |