The Erk/CREB Signaling Axis Mediates G-CSF-Promoted G-MDSC Survival in the Peripheral Blood of Melanoma-Bearing Mice
Yingying Sun, Yan Mo, Boya Xu, Chao Shang, Shu Jiang, Jing Xu, Yueshuang Ke, Xianlu Zeng · 2026
Read The Erk/CREB Signaling Axis Mediates G-CSF-Promoted G-MDSC Survival in the Peripheral Blood of Melanoma-Bearing Mice by Yingying Sun, Yan Mo, Boya Xu, Chao Shang, Shu Jiang, Jing Xu, Yueshuang Ke, Xianlu Zeng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13564542.txt.
Description
Yingying Sun and seven co-authors study immune cells that help tumors grow, in this 2026 mouse study. The cells, a type called G-MDSCs, block the body's defenses against cancer. Normal short-lived blood cells die off fast, yet these cells build up in animals with tumors, and the reason was not clear.
Using cell sorting and tests in living mice, the team found that a growth factor called G-CSF keeps the cells alive longer. The factor works through a chain of signals inside the cell, named Erk and CREB. Blocking that chain could make the cells die sooner. That, in turn, might slow the growth of melanoma, the skin cancer used in the study.
Catalog record
| CREATOR | Yingying Sun, Yan Mo, Boya Xu, Chao Shang, Shu Jiang, Jing Xu, Yueshuang Ke, Xianlu Zeng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |