Analgesic Efficacy of Continuous Bupivacaine Infusion versus Liposomal Bupivacaine in Parasacral Ischial Plane Block After Total Knee Arthroplasty: An Open-Label, Randomized, Controlled, Non-Inferiority Study
Xuan Pan, Peng Ye, Yawen Xie, Yingjie Chen, Hanliang Fan, Yongxin Huang, Chunying Zheng, Xiaochun Zheng, Ting Zheng · 2026
Read Analgesic Efficacy of Continuous Bupivacaine Infusion versus Liposomal Bupivacaine in Parasacral Ischial Plane Block After Total Knee Arthroplasty: An Open-Label, Randomized, Controlled, Non-Inferiority Study by Xuan Pan, Peng Ye, Yawen Xie, Yingjie Chen, Hanliang Fan, Yongxin Huang, Chunying Zheng, Xiaochun Zheng, Ting Zheng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13564457.txt.
Description
Xuan Pan and co-authors compare two ways of numbing the back of the knee after knee replacement surgery. Pain behind the knee is a stubborn gap in standard blocks. One trial arm used a continuous infusion of ordinary bupivacaine through a catheter in a deep hip-side plane. The other used a single shot of the long-acting liposomal form of the same drug in the same plane. One hundred patients were randomized.
Pain scores over the first seventy-two hours formed the main measure, with a preset margin for what counts as close enough. Both strict and full-group analyses confirmed the single shot was not worse than the drip. Rescue opioid use, recovery milestones, and side effects were also tracked. The authors present the one-shot liposomal option as a simpler route to the same relief, sparing patients a pump and catheter to manage.
Catalog record
| CREATOR | Xuan Pan, Peng Ye, Yawen Xie, Yingjie Chen, Hanliang Fan, Yongxin Huang, Chunying Zheng, Xiaochun Zheng, Ting Zheng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |