Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour · 2026
Read Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges by Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13564292.txt.
Description
Mohammad Amin Manavi and five co-authors offer a 2026 review of antimicrobial drugs reused as brain protectors. Drugs first made for infections also calm inflammation, cut oxidative stress, and tune immunity. The review weighs their promise in diseases such as Alzheimer and Parkinson disease, epilepsy, stroke, and brain injury.
Classes covered include tetracyclines, macrolides, antimalarial drugs, sulfones, and antiparasitic agents. The drugs act on microglia, cytokine output, cell pathways, and the gut-brain axis. That axis may sit at the center of their brain effects, the authors argue. Risks include resistance, off-target harm, and rule hurdles. The team calls the reuse path practical, since the drugs are already approved, but asks for sound trials.
Catalog record
| CREATOR | Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 97 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |