Nuclear IDH3A Drives Transcriptional Programs in Melanoma via the YBX1–JUN/FOS Axis
Juan Ran, Yanchun Fang, Shengming Ruan, Juling Wang, Songbai Liu, Yuan Mao, Dongsheng Hou, Yanping Wang, Zi Ye, Qiong Li, Daoxiang Zhang · 2026
Read Nuclear IDH3A Drives Transcriptional Programs in Melanoma via the YBX1–JUN/FOS Axis by Juan Ran, Yanchun Fang, Shengming Ruan, Juling Wang, Songbai Liu, Yuan Mao, Dongsheng Hou, Yanping Wang, Zi Ye, Qiong Li, Daoxiang Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13564267.txt.
Description
Juan Ran and co-authors uncover in 2026 an unexpected nuclear role for a metabolic enzyme in melanoma growth. The enzyme, IDH3A, normally helps run the cell's energy cycle and is overproduced in melanoma due to extra gene copies. Its rise boosted building-block molecules but not energy output, hinting at a different job inside these cancer cells.
Inside the nucleus, the enzyme partners with a transcription factor at the switches of two growth genes. That action blocks cell death and fuels tumors, without needing its chemical activity. A chaperone protein ferries it into the nucleus. Breaking that ferry route weakened the tumor effect.
Catalog record
| CREATOR | Juan Ran, Yanchun Fang, Shengming Ruan, Juling Wang, Songbai Liu, Yuan Mao, Dongsheng Hou, Yanping Wang, Zi Ye, Qiong Li, Daoxiang Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |