Palmitoyl Acyltransferase Zdhhc17 Promotes Functional Recovery After Spinal Cord Injury by Targeting the Nuclear Transport Factors Kpna2 and Ipo9
Meixuan Chen, Huan Chen, Sining Ding, Fan Liu, Xiaofei Zheng, Yuan Wang, Ruitu Tian, Huan Li, Peilin Liu, Le Hu, Bin Liu, Limin Rong, Mangmang Li · 2026
Read Palmitoyl Acyltransferase Zdhhc17 Promotes Functional Recovery After Spinal Cord Injury by Targeting the Nuclear Transport Factors Kpna2 and Ipo9 by Meixuan Chen, Huan Chen, Sining Ding, Fan Liu, Xiaofei Zheng, Yuan Wang, Ruitu Tian, Huan Li, Peilin Liu, Le Hu, Bin Liu, Limin Rong, Mangmang Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13564187.txt.
Description
Meixuan Chen and co-authors identify an enzyme that helps the spinal cord heal after injury, in a 2026 study. Adult mammals recover poorly from such injuries. Broken connections rarely rebuild, and neurons die. The enzyme attaches a fat tag to proteins. Raising it in neurons boosted axon regrowth in dishes and animals. Recovery of movement improved as well. The benefit depended on the enzyme's tagging activity.
The team hunted for the enzyme's targets in cortical neurons. Two nuclear transport proteins stood out. Injury lowers both proteins sharply. The fat tag protects them from destruction. Raising either protein copied the enzyme's benefits. One pairing even added further gains. Stress tests showed the enzyme also guards neurons against chemical harm. It switches on growth programs inside injured cells. The authors name the pathway a drug target for spinal repair.
Catalog record
| CREATOR | Meixuan Chen, Huan Chen, Sining Ding, Fan Liu, Xiaofei Zheng, Yuan Wang, Ruitu Tian, Huan Li, Peilin Liu, Le Hu, Bin Liu, Limin Rong, Mangmang Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |