The proteinase-activated receptor-2 mediates protective immunity in early experimental leishmaniasis
Yvonne Kusche, Niels Münck, Linda Nemetschke, Kirsten Roebrock, Lena Fischer-Riepe, Eva Nattkemper, Kerstin Vischedyk, Martin Steinhoff, Johannes Roth, Cord Sunderkötter, Jan Ehrchen · 2026
Read The proteinase-activated receptor-2 mediates protective immunity in early experimental leishmaniasis by Yvonne Kusche, Niels Münck, Linda Nemetschke, Kirsten Roebrock, Lena Fischer-Riepe, Eva Nattkemper, Kerstin Vischedyk, Martin Steinhoff, Johannes Roth, Cord Sunderkötter, Jan Ehrchen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13564165.txt.
Description
Kusche and ten co-authors study a cell switch that helps mice fight a skin parasite in this twenty twenty-six paper. Some mouse strains resist the parasite with one type of immune reply, while others get sick when the reply leans the other way. The switch in focus turns on when a blood-clotting factor is active in fresh skin wounds.
Inside, mice that lack the switch grew larger sores and held more parasites than normal mice. Their immune cells also leaned toward the weaker type of reply. When weak-strain mice got a drug that turns the switch on early, parasite counts fell and the reply leaned the strong way. The switch seems to shape the first hours of the fight.
Catalog record
| CREATOR | Yvonne Kusche, Niels Münck, Linda Nemetschke, Kirsten Roebrock, Lena Fischer-Riepe, Eva Nattkemper, Kerstin Vischedyk, Martin Steinhoff, Johannes Roth, Cord Sunderkötter, Jan Ehrchen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |