Pharmacological activation of SIRT1 alleviates sepsis-associated acute kidney injury by improving renal mitochondrial energy metabolism
Rui Zhu, Hairong Yang, Li Liu, Yuanyuan Gao, Xiaofang Gao · 2026
Read Pharmacological activation of SIRT1 alleviates sepsis-associated acute kidney injury by improving renal mitochondrial energy metabolism by Rui Zhu, Hairong Yang, Li Liu, Yuanyuan Gao, Xiaofang Gao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13564160.txt.
Description
Rui Zhu and co-authors test a drug that switches on a cell guardian to protect kidneys in sepsis, in a 2026 study. Sepsis often injures the kidneys, and that injury raises the risk of death. Faulty mitochondria, the cell's power plants, sit at the heart of the damage. The guardian protein SIRT1 helps control metabolism and cell stress.
The team modeled sepsis injury in rat kidney cells and in rats with induced sepsis. A drug that activates SIRT1 eased nearly every harm marker. A blocking drug made the same harms worse, which pins the effect on SIRT1 itself. Treated cells kept better energy levels and healthier power plants. The work names a drug target for a deadly sepsis complication.
Catalog record
| CREATOR | Rui Zhu, Hairong Yang, Li Liu, Yuanyuan Gao, Xiaofang Gao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |