Early de-escalation of antifungal treatment in critically ill immunocompromised patients with proven or probable invasive candidiasis: A retrospective multicentre study
Karim Jaffal, Constance Bayon, Louis Kreitmann, Anahita Rouzé, Marie Labruyere, Annabelle Stoclin, Jean Reignier, Guillaume Brunin, Anais Dartevel, Boualem Sendid, Julien Labreuche, Saad Nseir · 2026
Read Early de-escalation of antifungal treatment in critically ill immunocompromised patients with proven or probable invasive candidiasis: A retrospective multicentre study by Karim Jaffal, Constance Bayon, Louis Kreitmann, Anahita Rouzé, Marie Labruyere, Annabelle Stoclin, Jean Reignier, Guillaume Brunin, Anais Dartevel, Boualem Sendid, Julien Labreuche, Saad Nseir (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13564122.txt.
Description
Karim Jaffal and ten co-authors published this study in 2026. It asks how often doctors scale back antifungal treatment early in very sick patients with weakened immune systems. These patients face invasive candidiasis, a deep yeast infection, and early scaling back had never been checked in this group alone.
The study covered 242 patients across nineteen intensive care units in France from 2019 to 2024. In thirty-eight percent, treatment was stepped down within five days, either by switching to a narrower drug or by stopping outright. Death rates, time in intensive care, and days off a ventilator matched those of patients kept on full treatment. Only six patients needed the drugs restarted within a week. The authors say early de-escalation looks safe in this group.
Catalog record
| CREATOR | Karim Jaffal, Constance Bayon, Louis Kreitmann, Anahita Rouzé, Marie Labruyere, Annabelle Stoclin, Jean Reignier, Guillaume Brunin, Anais Dartevel, Boualem Sendid, Julien Labreuche, Saad Nseir |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |