Development and internal validation of a diagnostic prediction model for osteoporosis in elderly people living with HIV receiving antiretroviral therapy: a cross-sectional study

Description

Chuan Qin and nine colleagues build a calculator for spotting osteoporosis in older people living with HIV, whose treatment itself thins bone. Years of antiretroviral therapy erode density until a fracture announces it. Their 2026 study assembled 256 patients aged fifty or over, or postmenopausal, all on therapy for at least a year at one centre. Bone density scans sorted them by the threshold, and a shrinkage regression picked predictors from clinical and blood measures.

Just under forty percent, 102 patients, had osteoporosis. Seven variables survived into the nomogram. Its parts: sex, the ratio of age to body mass, years on therapy, starting CD4 count, tenofovir in its older form, and two blood markers of bone turnover. The model separated cases from non-cases with a concordance of 0.709, held up under resampling, and calibrated. The authors pitch it as a triage tool for clinics that cannot scan every ageing patient.

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Source: https://europepmc.org/article/MED/PMC13563893