Complete genome sequence of Streptomyces californicus ADR1, an anti-infective, anti-biofilm and anti-oxidant producing endophyte isolated from the medicinal plant Datura metel

Description

Khushboo Yadav and three colleagues publish the complete genome of a bacterium that lives inside a medicinal plant and makes compounds able to kill priority drug-resistant germs. The strain, Streptomyces californicus ADR1, was isolated from Datura metel and had already shown antibacterial, anti-biofilm, and antioxidant powers in the dish. Its chemistry hinted at rich biosynthetic machinery. Their 2026 data report sequences that machinery end to end, so the genes behind the effects can be found and mined.

The genome spans 8.4 million bases across 262 scaffolds, with a high G+C content of 72.5 percent and 7,427 protein-coding genes. Mining software flagged 39 biosynthetic gene clusters, spanning non-ribosomal peptide makers, polyketide assembly lines, terpenes, and melanin pathways. Those clusters line up with the compound families earlier chemical profiling had detected. The authors present the sequence as a working map for turning a plant-dwelling microbe's hidden chemistry into candidate medicines.

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Source: https://europepmc.org/article/MED/PMC13563878