Imaging-based versus threshold assessment-based deep brain stimulation programming in Parkinson’s disease: study protocol for a randomized controlled trial {1a}
Annabel van der Weide, Yarit Wiggerts, Martijn Beudel, Jeroen Hoogland, Maarten Bot, Rick Schuurman, Rob de Bie · 2026
Read Imaging-based versus threshold assessment-based deep brain stimulation programming in Parkinson’s disease: study protocol for a randomized controlled trial {1a} by Annabel van der Weide, Yarit Wiggerts, Martijn Beudel, Jeroen Hoogland, Maarten Bot, Rick Schuurman, Rob de Bie (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13563839.txt.
Description
Annabel van der Weide and six colleagues lay out the protocol for a trial asking whether brain imaging can replace the tuning of brain stimulators in Parkinson's disease. Stimulation of the subthalamic nucleus eases motor swings, but picking contacts and settings by bedside testing takes hours. Their 2026 protocol describes a single-centre randomised trial of 132 patients, split between imaging-guided programming and the threshold-based review. Assessors who score the outcomes will not know which arm each patient sits in.
The imaging arm builds a 3D model from MRI and post-surgery CT, simulating which tissue each contact would activate. The main measure is change in a motor score, off medication, six months after programming. Secondary measures cover daily life, side effects, satisfaction, care use, and how long programming takes. The design tests non-inferiority: imaging need only match the standard to win on speed and stability.
Catalog record
| CREATOR | Annabel van der Weide, Yarit Wiggerts, Martijn Beudel, Jeroen Hoogland, Maarten Bot, Rick Schuurman, Rob de Bie |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48127 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |