Soluble CD25 as a potential prognostic biomarker for pediatric septic shock and its comparison with hemophagocytic lymphohistiocytosis
T B Garcia, V Knight, H F Scott · 2026
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Description
T. B. Garcia and two colleagues test a blood marker borrowed from a rare immune disorder as a warning in children arriving with septic shock. Spotting which child will deteriorate during emergency evaluation is hard. The marker, soluble CD25, is a diagnostic pillar of hemophagocytic lymphohistiocytosis, an immune condition that overlaps sepsis and worsens it. Their 2026 study compared levels across children with that disorder, children with septic shock, and children with infection but no sepsis.
The disorder group towered over the rest, at a median of 25,800 picograms per millilitre against about 5,200 for septic shock. Shock and plain infection groups overlapped on average, yet a slice of shock patients reached disorder-level values. That slice fared badly: every one needed intensive care, half needed circulation drugs, and stays stretched to sixteen days. Bloodstream infections carried the highest levels. The authors call for larger studies to confirm the marker.
Catalog record
| CREATOR | T B Garcia, V Knight, H F Scott |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 21168 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |