Low-dose esketamine for postoperative fatigue after gynecological laparoscopic surgery: a randomized controlled trial
Ge Sun, Wentao Lin, Yujin Peng, Zhuming Liang, Haiming Liao, Jun Zhou, Fuhu Song · 2026
Read Low-dose esketamine for postoperative fatigue after gynecological laparoscopic surgery: a randomized controlled trial by Ge Sun, Wentao Lin, Yujin Peng, Zhuming Liang, Haiming Liao, Jun Zhou, Fuhu Song (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13563812.txt.
Description
Ge Sun and six colleagues infuse a low dose of esketamine during gynaecological surgery and measure whether patients wake up less exhausted. Postoperative fatigue delays recovery and no proven counter exists. Their 2026 trial was single-centre, double-blind, and placebo-controlled: women having elective laparoscopic surgery were randomised to an esketamine drip during the operation or to saline. Fatigue on the first day after surgery, scored on the Chalder scale, was the main outcome, with recovery quality, pain, drug use, and safety events tracked.
Fatigue struck 23.3 percent of the esketamine group against 40.0 percent of controls, a difference on the edge of significance at P = 0.050, firmer in the follow-up sensitivity analysis. Fatigue scores, recovery quality, and pain ran better on the first and third days, and the group needed less opioid and less blood-pressure support. Harm events matched. The authors call the drug promising for smoother recoveries.
Catalog record
| CREATOR | Ge Sun, Wentao Lin, Yujin Peng, Zhuming Liang, Haiming Liao, Jun Zhou, Fuhu Song |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62152 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |