Intravitreal aflibercept 8 mg in patients with neovascular age-related macular degeneration from China: 48-week results from the PULSAR trial
Xiaodong Sun, Hong Dai, Youxin Chen, Xufang Sun, Liming Tao, Jun Xiao, Mei Han, Mingwei Zhao, Li Wang, Andrea Schulze, Ursula Maria Schmidt-Ott, Min Zhao, Xin Zhang, Zhaohong Wang, Sergio Leal, Wenbin Wei · 2026
Read Intravitreal aflibercept 8 mg in patients with neovascular age-related macular degeneration from China: 48-week results from the PULSAR trial by Xiaodong Sun, Hong Dai, Youxin Chen, Xufang Sun, Liming Tao, Jun Xiao, Mei Han, Mingwei Zhao, Li Wang, Andrea Schulze, Ursula Maria Schmidt-Ott, Min Zhao, Xin Zhang, Zhaohong Wang, Sergio Leal, Wenbin Wei (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13563726.txt.
Description
Xiaodong Sun and fifteen colleagues report how a stronger eye injection performed in Chinese patients within the global PULSAR trial for wet age-related macular degeneration. The disease leaks fluid into the retina and steals central vision. The trial compared aflibercept at 8 milligrams, given every 12 or 16 weeks after starter doses, against the standard 2 milligrams every 8 weeks. This 2026 analysis covers the China subgroup through week 48, describing vision change, retinal thickness, staying power, and safety.
Vision gains were healthy in all arms: 13.2 letters on the eye chart for the 12-week group, 9.7 for the 16-week group, and 10.0 for standard care, with group sizes of 31, 31, and 39. Retinal swelling fell by similar amounts everywhere. Most patients held their long intervals, 88.5 percent at 12 weeks and 73.1 percent at 16. Eye side effects matched across arms, echoing the full trial's verdict.
Catalog record
| CREATOR | Xiaodong Sun, Hong Dai, Youxin Chen, Xufang Sun, Liming Tao, Jun Xiao, Mei Han, Mingwei Zhao, Li Wang, Andrea Schulze, Ursula Maria Schmidt-Ott, Min Zhao, Xin Zhang, Zhaohong Wang, Sergio Leal, Wenbin Wei |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39832 |
| LICENSE | https://creativecommons.org/publicdomain/zero/1.0 |
| RIGHTS | CC0 |
| SOURCE | Europe PMC |