Integrative transcriptomic analysis identifies meningeal-hippocampal immune communication in Alzheimer’s disease
Congcong Yan, Zhoushuai Chen, Yi Yan, Miao Wang, Wenting Chen, Feifan Zhou, Qian Liu · 2026
Read Integrative transcriptomic analysis identifies meningeal-hippocampal immune communication in Alzheimer’s disease by Congcong Yan, Zhoushuai Chen, Yi Yan, Miao Wang, Wenting Chen, Feifan Zhou, Qian Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13563725.txt.
Description
Congcong Yan and six colleagues trace molecular conversations between the meninges, the immune-active membranes wrapping the brain, and the hippocampus in Alzheimer's disease. How those membranes talk to the vulnerable memory region was largely unknown. Their 2026 study used two mouse models, one for amyloid disease and one for tau disease, layering bulk gene sequencing, protein measurement, and spatial gene mapping across disease stages. The design separated true disease signals from ordinary ageing.
A sturdy 19-gene hippocampal signature emerged, repeating in an independent dataset from each model. Spatial maps defined a progression axis along which meningeal spots clustered at the advanced end. Message-and-receiver analysis nominated signalling pairs between the tissues, tied to the states of microglia, the brain's immune cells. The authors are explicit that these computer-inferred channels, drawn from mice, are hypotheses. Human tissue checks and perturbation tests must come before any treatment talk.
Catalog record
| CREATOR | Congcong Yan, Zhoushuai Chen, Yi Yan, Miao Wang, Wenting Chen, Feifan Zhou, Qian Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45788 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |