Effects of advanced platelet-rich fibrin combined with a collagen membrane on human periodontal ligament stem cells at two extract concentrations: an in vitro study
Meo Nguyen, Bao Quoc Minh Nguyen, Truong Thien Tran, Ha Le Bao Tran, Thu Ngoc Yen Nguyen, Thi Hoa Ho, Ha Viet Nguyen, Nam Cong-Nhat Huynh · 2026
Read Effects of advanced platelet-rich fibrin combined with a collagen membrane on human periodontal ligament stem cells at two extract concentrations: an in vitro study by Meo Nguyen, Bao Quoc Minh Nguyen, Truong Thien Tran, Ha Le Bao Tran, Thu Ngoc Yen Nguyen, Thi Hoa Ho, Ha Viet Nguyen, Nam Cong-Nhat Huynh (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13563724.txt.
Description
Meo Nguyen and seven colleagues test, in dishes, whether adding a collagen membrane changes how a blood-derived material treats gum ligament stem cells. Advanced platelet-rich fibrin, spun from a patient's blood, is a staple of gum regeneration, and collagen membranes partner it in surgery. Whether the pairing helps or hinders the cells was unclear. The 2026 study soaked the materials into extracts at full strength and at 20 percent, using fibrin from four donors, then fed them to periodontal ligament stem cells.
Only the full-strength combined extract met the toxicity bar, while full-strength fibrin alone wobbled near it, unevenly across donors. Growth activity peaked around day five for all groups. In a scratch test, diluted extracts closed the gap better than full-strength ones, and fibrin beat the pairing at 20 percent. The authors call the pairing's profile mixed and in need of tuning, not an upgrade.
Catalog record
| CREATOR | Meo Nguyen, Bao Quoc Minh Nguyen, Truong Thien Tran, Ha Le Bao Tran, Thu Ngoc Yen Nguyen, Thi Hoa Ho, Ha Viet Nguyen, Nam Cong-Nhat Huynh |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44506 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |