Reprogramming PD-L1 endosomal recycling and lysosomal degradation via engineered exosome-based nanocomposites overcomes immune resistance in lung cancer brain metastasis
Xiujuan Hong, Xiaoqi Wang, Wankun Wang, Weiye Ren, Wenjia Ding, Dashan Yin, Chenli Wang, Chuan Sun, Jun Chen, Ji-Gang Piao, Zhibing Wu · 2026
Read Reprogramming PD-L1 endosomal recycling and lysosomal degradation via engineered exosome-based nanocomposites overcomes immune resistance in lung cancer brain metastasis by Xiujuan Hong, Xiaoqi Wang, Wankun Wang, Weiye Ren, Wenjia Ding, Dashan Yin, Chenli Wang, Chuan Sun, Jun Chen, Ji-Gang Piao, Zhibing Wu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13563566.txt.
Description
Hong and co-authors engineer a tiny delivery system against lung cancer that has spread to the brain, in a 2026 study. Drugs that block PD-L1, a shield cancer cells use against the immune system, work poorly in the brain. The blood-brain barrier keeps them out, and tumors there suppress immune attack. The team wrapped the drug and a second agent inside exosomes, small sacs shed by tumor cells, tuned to home to brain tumors.
The package crosses the barrier and releases its cargo in the acidic tumor setting. One agent floods the tumor with reactive oxygen and kills cells directly. It also forces PD-L1 into the cell's disposal routes, clearing the shield from within while the antibody blocks it outside. The combined attack reshaped the immune setting inside the skull in their tests.
Catalog record
| CREATOR | Xiujuan Hong, Xiaoqi Wang, Wankun Wang, Weiye Ren, Wenjia Ding, Dashan Yin, Chenli Wang, Chuan Sun, Jun Chen, Ji-Gang Piao, Zhibing Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 85 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |