Unraveling causal links between chronic rhinosinusitis and peripheral artery diseases: insights from genetic correlations through genome-wide association studies
Bo Wei, Jiaoyu He, Weigang Gan, Binbin Wang, Feng Liu · 2026
Read Unraveling causal links between chronic rhinosinusitis and peripheral artery diseases: insights from genetic correlations through genome-wide association studies by Bo Wei, Jiaoyu He, Weigang Gan, Binbin Wang, Feng Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13563561.txt.
Description
Bo Wei and co-authors ask whether chronic sinus inflammation and artery disease share roots in the genes. Sinus disease tracks with heart and vessel trouble in population data, but the shared biology was murky. The team mined large genome-wide studies of European ancestry for overlap, then tested cause with Mendelian randomization.
The two conditions did share genetic signals, sorted into three paths covering artery disease, heart muscle disease, and heart failure. One stretch of chromosome 6 tied sinus disease to peripheral artery disease in particular. The causal arrow ran from sinus disease toward artery disease, not back. Certain gene settings, such as HLA-DRB1 and APOM, looked protective, while HLA-DQA2 raised risk. Lab tests in vessel cells backed the pattern.
Catalog record
| CREATOR | Bo Wei, Jiaoyu He, Weigang Gan, Binbin Wang, Feng Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |