Divergent transcriptional programs and constrained metabolic states reveal selective metabolic dependencies in chemoresistant luminal breast cancer
Melis Poyraz, Buse Sari, Jérôme Ambroise, Melanie Spears, Martin Michaelis, Jindrich Cinatl Jr., Romain Boidot, Kristian Serafimov, Olivier Feron, François P. Duhoux, Manon Desgres, Cyril Corbet · 2026
Read Divergent transcriptional programs and constrained metabolic states reveal selective metabolic dependencies in chemoresistant luminal breast cancer by Melis Poyraz, Buse Sari, Jérôme Ambroise, Melanie Spears, Martin Michaelis, Jindrich Cinatl Jr., Romain Boidot, Kristian Serafimov, Olivier Feron, François P. Duhoux, Manon Desgres, Cyril Corbet (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13563457.txt.
Description
Melis Poyraz leads a twelve-author team probing why some hormone-sensitive breast cancers resist chemotherapy, in a study from two thousand twenty-six. Anthracyclines and taxanes are the standard drugs given before surgery. The metabolic rewiring behind resistance to each drug was mapped in poor detail till now.
Two cell lines and their drug-resistant offspring were set side by side. Multi-omics profiling, flux measurements, and drug inhibition tests were brought to bear as one. Patient datasets validated the lab patterns. Resistant cells showed reduced drug sensitivity and distinct transcriptional programs. Their metabolic states were constrained, in ways tied to each drug. Those limits lay bare selective dependencies, the team argues. A dependency found just in resistant cells is a good place to aim second-line treatments.
Catalog record
| CREATOR | Melis Poyraz, Buse Sari, Jérôme Ambroise, Melanie Spears, Martin Michaelis, Jindrich Cinatl Jr., Romain Boidot, Kristian Serafimov, Olivier Feron, François P. Duhoux, Manon Desgres, Cyril Corbet |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |