Advances and challenges in immunotherapy for intrahepatic cholangiocarcinoma based on the tumour immune microenvironment
Mengyao Chen, Shuofan Jin, Yuxuan Zhou, Jinkai Tong, Yufan Zhao, Quanjun Yang · 2026
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Description
Mengyao Chen and co-authors review immune treatment for a cancer of the bile ducts inside the liver, in a paper published in 2026. This cancer is aggressive and varied, and lasting control stays rare even with surgery, chemotherapy, and newer targeted drugs. Immune drugs that release the brakes on immune cells offer hope but often stall.
The review maps the tumor's immune surroundings: dense scar-like tissue, suppressive cells, weak antigen display, and altered cell fuel use all help the cancer hide. The authors weigh trial evidence for drug pairs, discuss gene changes that may shape response, and survey next steps such as cell therapies and vaccines. They stress that proof specific to this cancer type is still young.
Catalog record
| CREATOR | Mengyao Chen, Shuofan Jin, Yuxuan Zhou, Jinkai Tong, Yufan Zhao, Quanjun Yang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |