Metabolic reprogramming and immune evasion interaction in the tumor microenvironment promote tumor progression
Hailun Wang, Hanyu Zhao, Xuelu Pu, Yandu He, Yajun Li · 2026
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Description
Hailun Wang and four co-authors review how tumors rewire their fuel use to hide from the immune system, in a 2026 paper. Changed metabolism does more than feed fast growth. It also floods the tissue around the tumor with byproducts and starves immune cells of nutrients, building a zone where immune attack is suppressed.
The review follows two main threads. The first is sugar burning that piles up lactate, a waste product that also sends signals and marks genes in ways that quiet immune programs. The second is competition for amino acids and fats, which weakens killer cells while favoring cells that calm the immune response. Low oxygen in the tumor amplifies both threads. The authors survey drugs aimed at this metabolism-immunity link, while warning that effects vary by cell type and that clinical proof is still thin.
Catalog record
| CREATOR | Hailun Wang, Hanyu Zhao, Xuelu Pu, Yandu He, Yajun Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |