Postburn Downregulation of miR‐148a‐3p and Its Regulatory Mechanism in Hypertrophic Scar Formation
Yanhua Lu, Meng Yu, Jinghe Zhou, Yang Yang · 2026
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Description
Yanhua Lu, Meng Yu, Jinghe Zhou, and Yang Yang study in 2026 why thick, raised scars form after burns. They focus on a tiny bit of RNA in blood and skin cells that helps set how genes act. Blood tests showed less of this RNA in burn patients than in healthy people, and still less in those who went on to form thick scars.
In lab tests, skin cells hurt by heat also held less of the RNA. When the team raised its level, the cells grew and moved less and made less scar protein. The RNA works by binding a gene called MEOX2 and holding it down, and raising that gene undid the effect. Low levels of the RNA may flag who will scar, and it may serve as a target to stop thick scars.
Catalog record
| CREATOR | Yanhua Lu, Meng Yu, Jinghe Zhou, Yang Yang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |