Antiplasmodial Activity of Methylangolensate From Entandrophragma angolense (Welw.) C.DC. Stem Bark: An In Vitro and In Silico Approach
Jude Tetteh, Jemima Aggrey Appiah, Felix Zoiku, Derwaa Keteku, Bismark Aboagye-Adjei, Arnold Donkor Forkuo, Isaac Kingsley Amponsah, Charles Ansah, Kwesi Boadu Mensah · 2026
Read Antiplasmodial Activity of Methylangolensate From Entandrophragma angolense (Welw.) C.DC. Stem Bark: An In Vitro and In Silico Approach by Jude Tetteh, Jemima Aggrey Appiah, Felix Zoiku, Derwaa Keteku, Bismark Aboagye-Adjei, Arnold Donkor Forkuo, Isaac Kingsley Amponsah, Charles Ansah, Kwesi Boadu Mensah (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13563057.txt.
Description
Malaria still needs new drugs, and one candidate comes from the bark of the tree Entandrophragma angolense. Jude Tetteh and co-authors test a bark compound, methylangolensate (MAL), against the malaria parasite Plasmodium falciparum. They check how well it kills the parasite in lab cultures and how much harm it does to human liver cells. Computer models test how tightly it binds to proteins the parasite needs to live.
MAL did little harm to liver cells, even at high doses. It worked well against the blood stages of two parasite strains, one drug resistant, and had a weaker effect on the sexual stage that spreads it. The compound passed standard drug-likeness rules and bound strongly to several parasite proteins, some tied to folate use. Tests with added folic acid backed the idea that it blocks that path, so the team sees MAL as a lead for new malaria drugs.
Catalog record
| CREATOR | Jude Tetteh, Jemima Aggrey Appiah, Felix Zoiku, Derwaa Keteku, Bismark Aboagye-Adjei, Arnold Donkor Forkuo, Isaac Kingsley Amponsah, Charles Ansah, Kwesi Boadu Mensah |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 75 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |