Single‐Cell Transcriptomic Analysis Reveals Ferroptosis‐Related Signatures and Tumor Microenvironment Heterogeneity in Epithelial Ovarian Cancer
Jie Liu, Jing Li, Bingxin Li, Hui Liang · 2026
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Description
Jie Liu and co-authors map a cell death pathway in ovarian cancer in a 2026 study. The cancer is the deadliest of its class. Ferroptosis, a death mode driven by iron and fat damage, offers a new attack route. Using single-cell gene data from eleven patients, the team charted which cells resist that death and why.
More than fifty thousand cells fell into eighteen groups. Cancer cells showed high activity of a master shield gene, NRF2, which blunts ferroptosis. Silencing that gene made drug-induced death far stronger in lab tests. Tumors that resisted platinum drugs also showed shifted pathway scores. Readers get targets for cracking drug resistance.
Catalog record
| CREATOR | Jie Liu, Jing Li, Bingxin Li, Hui Liang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |