The vicious cycle of SASP and inflammaging promotes aging and age-related diseases
Qian Liu, Yulin Zheng, Chongkui Sun · 2026
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Description
Liu, Zheng, and Sun review how aging cells and chronic inflammation feed each other in a 2026 paper. Senescent cells pile up in old tissues and release a cocktail of signals called SASP. Brief signaling aids repair, but lasting signaling harms.
The leaked factors damage neighbors, spread senescence, and upset immune balance. That creates a self-reinforcing loop the authors call a vicious cycle with inflammaging. Their framework sorts the process by duality, cycle, and tissue specificity. Different tissues suffer in different ways, so therapy should match context. The review covers mechanisms and emerging strategies to break the loop. It aims to guide treatment design for age-related diseases.
Catalog record
| CREATOR | Qian Liu, Yulin Zheng, Chongkui Sun |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |