AAT/SERPINA1 Pi*Z variant linked to gestational length and preterm birth prevention via AAT in mice
E Koivulehto, A Pasanen, A M Haapalainen, H Tiensuu, M Rämet, M Hallman · 2026
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Description
Koivulehto and co-authors link a gene variant to early birth in a 2026 study. About one in ten pregnancies ends before term, and no strong guard exists. The gene makes alpha-1-antitrypsin, a guard protein, and rare faults in it clustered in families with repeat early births.
One common variant tied firmly to pregnancy length in European-ancestry mothers. Mothers with two copies carried about nine days shorter and faced fourfold odds of early birth. Placenta reads showed low protein in early births. Mouse work then tests whether topping up the protein can hold a pregnancy longer. Gene and animal lines point the same way.
Catalog record
| CREATOR | E Koivulehto, A Pasanen, A M Haapalainen, H Tiensuu, M Rämet, M Hallman |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |