Sustained intravitreal delivery of carnosic acid by RADA16 peptide hydrogel protects the retina in acute ocular hypertension
Hao Hu, Yiyao Wang, Dadong Jia, Shi Luo, Yi Fan Deng, Ruwen Wang, Xiaoyu Liu, Xuelian Guo, Gang Wu, JingYi Sun, Liang Liang · 2026
Read Sustained intravitreal delivery of carnosic acid by RADA16 peptide hydrogel protects the retina in acute ocular hypertension by Hao Hu, Yiyao Wang, Dadong Jia, Shi Luo, Yi Fan Deng, Ruwen Wang, Xiaoyu Liu, Xuelian Guo, Gang Wu, JingYi Sun, Liang Liang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13562530.txt.
Description
Hao Hu and ten colleagues package a plant-derived protective compound into a self-assembling gel that slowly releases it inside the eye. Glaucoma kills the nerve cells of the retina, and pressure control alone does not stop that loss. Carnosic acid, drawn from herbs, guards nerve cells, yet getting it to the retina and keeping it there is hard. The 2026 team loaded it into RADA16, a peptide that forms a soft, porous gel, and tested three strengths to pick one soft enough for injection.
The chosen gel released the compound over 72 hours. In cell tests the loaded gel supported growth and proved gentle at working doses. In rats with a sudden pressure spike in the eye, the treatment thinned the damage: fewer stressed cells, lower inflammatory signals, and better cell survival. The authors see a route toward long-acting eye protection from one injection.
Catalog record
| CREATOR | Hao Hu, Yiyao Wang, Dadong Jia, Shi Luo, Yi Fan Deng, Ruwen Wang, Xiaoyu Liu, Xuelian Guo, Gang Wu, JingYi Sun, Liang Liang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 76337 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |