UCA1 copy number gain in serum cfDNA predicts next-generation antiandrogen resistance in metastatic castration-resistant prostate cancer
Anita Csizmarik, Áron Soós, Melinda Váradi, Balázs Magyar, Martin Puhr, Ákos Nagy, Balázs Győrffy, Gergő Holló, Gero Kramer, Mulham Al-Nader, Osama Mahmoud, Boris Hadaschik, Péter Nyirády, Tibor Szarvas · 2026
Read UCA1 copy number gain in serum cfDNA predicts next-generation antiandrogen resistance in metastatic castration-resistant prostate cancer by Anita Csizmarik, Áron Soós, Melinda Váradi, Balázs Magyar, Martin Puhr, Ákos Nagy, Balázs Győrffy, Gergő Holló, Gero Kramer, Mulham Al-Nader, Osama Mahmoud, Boris Hadaschik, Péter Nyirády, Tibor Szarvas (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13562513.txt.
Description
Anita Csizmarik and thirteen colleagues hunt for a blood signal that warns when a prostate cancer drug is about to fail. Enzalutamide, a hormone-blocking drug, extends life in advanced prostate cancer, yet many tumours resist it from the start. No test currently guides that choice. The 2026 team first grew prostate cancer cell pairs, one sensitive and one resistant to the drug, and compared their genes and DNA. Three candidates emerged, among them a stretch called UCA1 and the androgen receptor gene.
The researchers then counted copies of each candidate in cell-free DNA from patients' blood serum. Groups covered 20 men on enzalutamide, 20 on a related drug, and 40 on chemotherapy. Extra UCA1 copies went with shorter survival on enzalutamide, while extra receptor copies mattered for the related drug only. The authors suggest a simple blood count could help doctors pick the right drug sooner.
Catalog record
| CREATOR | Anita Csizmarik, Áron Soós, Melinda Váradi, Balázs Magyar, Martin Puhr, Ákos Nagy, Balázs Győrffy, Gergő Holló, Gero Kramer, Mulham Al-Nader, Osama Mahmoud, Boris Hadaschik, Péter Nyirády, Tibor Szarvas |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29446 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |