Disulfidptosis-related signatures identify SPARC+/CYR61+ stromal cells mediating immunosuppression in gastric cancer
Yuxuan Xu, Xianming Kong, Jin Li, Dongxi Xiang · 2026
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Description
Yuxuan Xu and three colleagues examine a recently described form of cell death, disulfidptosis, and what its gene signature means for stomach cancer. The death pathway triggers when cells starve for glucose, yet its link to patient outcomes was unclear. The 2026 study merged single-cell and bulk gene data from tumours to find core genes, built a survival model, and mapped how marked cells talk to immune cells. Three genes stood out: SPARC, CYR61, and TIMP1.
High signature scores went with certain mutations and with tumours emptied of immune activity. Cells carrying SPARC and CYR61 sat mostly in vessel lining and fibroblast populations, the support tissue of the tumour. Signalling from those cells appeared to quiet B cells, T cells, and other immune defenders through named receptor pathways. The authors propose the signature as a forecast tool and a guide for tailoring immune therapy.
Catalog record
| CREATOR | Yuxuan Xu, Xianming Kong, Jin Li, Dongxi Xiang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44198 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |