The histone demethylase KDM5C aggravates titanium particle-induced osteolysis by promoting macrophage inflammation and osteoclastogenesis
Zeming Lei, Liangzi Yin, Bin Zhang, Ziyuan Wang, Yansheng Wang, Lunhao Bai · 2026
Read The histone demethylase KDM5C aggravates titanium particle-induced osteolysis by promoting macrophage inflammation and osteoclastogenesis by Zeming Lei, Liangzi Yin, Bin Zhang, Ziyuan Wang, Yansheng Wang, Lunhao Bai (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13562459.txt.
Description
Zeming Lei and five colleagues study a gene regulator called KDM5C and its part in the bone loss that can loosen artificial joints. Tiny titanium particles shed by implants stir up immune cells named macrophages, which then drive bone-eating cells and eat away the bone holding the implant. The 2026 study found KDM5C levels rose in macrophages exposed to titanium particles in the dish. The team blocked the gene in cells and in a mouse skull model of the disease.
Blocking KDM5C calmed the inflammatory signals and cut the formation of bone-eating cells. The regulator works by stripping a chemical tag from DNA near a protective gene, NFE2L2, and switching that gene down. Silencing NFE2L2 erased the benefit, which pins down the pathway. Treated mice lost less bone. The authors propose KDM5C as a drug target for wear-particle bone loss.
Catalog record
| CREATOR | Zeming Lei, Liangzi Yin, Bin Zhang, Ziyuan Wang, Yansheng Wang, Lunhao Bai |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42548 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |