Purkinje cell arrival at the Purkinje cell layer orchestrates cerebellar foliation and its temporal sequence
Ryosuke Uchi, Takao Honda, Takuto Kasai, Yuki Hirota, Kazunori Nakajima · 2026
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Description
Ryosuke Uchi and co-authors show how arriving cells set the folds of the cerebellum in this 2026 study. The cerebellum's folds form in a fixed order, but the clock behind that order was unclear. In mutant mice, misplaced Purkinje cells and bad folds appear together, with cause unknown.
The team deleted a gene, DAB1, in Purkinje cells at chosen times after birth. Late arrival at their layer spoiled folds in two lobes. Even slight displacement cut the growth of granule cell precursors nearby. Adding back a signal, Sonic hedgehog, rescued the folds. Arrival time, it seems, runs the schedule.
Catalog record
| CREATOR | Ryosuke Uchi, Takao Honda, Takuto Kasai, Yuki Hirota, Kazunori Nakajima |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |