Nociception-guided opioid administration within multimodal analgesia for laparoscopic endometriosis surgery: a randomized controlled trial
Hoang-Thi Buis, Joana Berger-Estilita, Sina Zirngast, Paul Ranner, Tihomir Piskor, Isabel Marcolino · 2026
Read Nociception-guided opioid administration within multimodal analgesia for laparoscopic endometriosis surgery: a randomized controlled trial by Hoang-Thi Buis, Joana Berger-Estilita, Sina Zirngast, Paul Ranner, Tihomir Piskor, Isabel Marcolino (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13562212.txt.
Description
Hoang-Thi Buis and colleagues test whether a pain-signal monitor guiding opioid dosing beats standard bedside judgment during keyhole endometriosis surgery. Their 2026 randomized, single-blinded trial assigns 111 women not yet in menopause to monitor-guided dosing or usual care checks, both inside the same layered pain plan. Women with endometriosis face stronger after-surgery pain from sensitized pain pathways.
Total opioid use did not differ clearly between the groups for either fentanyl or remifentanil in the adjusted comparison. Pain scores matched at every postoperative checkpoint, and recovery room stays matched too. Surgery length, not group, tracked both opioid use and recovery time. Monitor readings themselves showed no association with drug use or pain. Higher pre-surgery pain ratings on a set scale did predict worse late recovery pain. The authors conclude the device added nothing over good standard care here.
Catalog record
| CREATOR | Hoang-Thi Buis, Joana Berger-Estilita, Sina Zirngast, Paul Ranner, Tihomir Piskor, Isabel Marcolino |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44098 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |