Adipose Tissue Remodeling Beyond Weight Loss: New Insights Into Incretin-Based Therapies and Bariatric Surgery
Gabriela Ferreira Abud, Ellen Cristini de Freitas, Kristin I. Stanford · 2026
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Description
Gabriela Ferreira Abud and co-authors review how fat tissue itself changes when people lose weight on modern obesity drugs or through surgery. In obesity, fat depots remodel in harmful ways: structure shifts, the matrix stiffens, hormone signals warp, and mitochondria falter. The review asks whether incretin-based drugs and bariatric surgery reshape fat beyond simply shrinking it.
Studies in animals and humans link both treatments to calmer inflammation and stronger heat-making and hormone pathways in fat. Yet the human evidence on mechanism is mixed, and tissue is hard to sample. Effects also differ between the fat under the skin and the fat around the organs. The authors call for long, tissue-level human studies to split true remodeling from plain weight loss.
Catalog record
| CREATOR | Gabriela Ferreira Abud, Ellen Cristini de Freitas, Kristin I. Stanford |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 95 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |