PYCR1 promotes glutamine metabolism and the progression of lung adenocarcinoma by regulating the expression of OPLAH
Wei Chen, Kai Wang, Renyu Wang, Xufeng Deng, Xiaobing Liu, Peng Dai, Quanxing Liu · 2026
Read PYCR1 promotes glutamine metabolism and the progression of lung adenocarcinoma by regulating the expression of OPLAH by Wei Chen, Kai Wang, Renyu Wang, Xufeng Deng, Xiaobing Liu, Peng Dai, Quanxing Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13562194.txt.
Description
Wei Chen and colleagues establish PYCR1, an enzyme of proline synthesis, as a driver of glutamine metabolism in lung adenocarcinoma. Their 2026 study mines cancer atlas data, validates in public datasets and single-cell sequencing, then tests the gene in cells and in tumors grown in mice. Six glutamine-related genes stood out as overactive in tumors and tied to poor survival.
PYCR1 concentrated in the malignant cells themselves. Forcing it higher made cancer cells take up more glutamine, multiply faster, and resist death, working partly by suppressing the guardian pathway of p53. The enzyme also switched on OPLAH, a partner gene that amplified its cancer-promoting effects. Tumors carrying extra PYCR1 grew faster in the animal model. The authors name the PYCR1 and OPLAH pair an axis worth drugging in the commonest form of lung cancer.
Catalog record
| CREATOR | Wei Chen, Kai Wang, Renyu Wang, Xufeng Deng, Xiaobing Liu, Peng Dai, Quanxing Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57163 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |