Aryl hydrocarbon receptor promotes the proliferation and aggressive progression of colorectal cancer under high-fat diet via activating INPP4B/AKT/SGK3 signaling pathway
Qiguan Dong, Tong Wu, Yuchao Yang, Yan Yang, Bo Gao, Dianzhi Shi, Hengjiao Wang, Ying Yan · 2026
Read Aryl hydrocarbon receptor promotes the proliferation and aggressive progression of colorectal cancer under high-fat diet via activating INPP4B/AKT/SGK3 signaling pathway by Qiguan Dong, Tong Wu, Yuchao Yang, Yan Yang, Bo Gao, Dianzhi Shi, Hengjiao Wang, Ying Yan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13561949.txt.
Description
Dong and co-authors trace how a fat rich diet speeds colon cancer through a sensor protein in the gut. High fat diets are a known risk for this cancer's progress, and the sensor, called AhR, is plentiful in intestinal tissue. Their 2026 study builds obese tumor bearing mice on the diet and treats cancer cells with fatty acids in dishes.
The diet sped tumor growth and spread while switching the sensor on and raising its activating chemical in tissue and blood. Blocking the sensor eased growth and spread. In cells, fatty acids drove growth, invasion, and shape change through the same switch, and silencing it reversed the effects. The chain runs through one target gene into a growth pathway. The authors name it a candidate point for prevention or treatment.
Catalog record
| CREATOR | Qiguan Dong, Tong Wu, Yuchao Yang, Yan Yang, Bo Gao, Dianzhi Shi, Hengjiao Wang, Ying Yan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 73 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |