Prognostic value of systemic immune-inflammation index in patients with localized and advanced renal cell carcinoma: a systematic review and meta-analysis
Huan Zhang, Dan Yang, Liuyue Zeng, Weidong Wang, Zongxin Guo, Dan Liao · 2026
Read Prognostic value of systemic immune-inflammation index in patients with localized and advanced renal cell carcinoma: a systematic review and meta-analysis by Huan Zhang, Dan Yang, Liuyue Zeng, Weidong Wang, Zongxin Guo, Dan Liao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13561734.txt.
Description
Huan Zhang and colleagues pool published findings on the systemic immune-inflammation index as a prognostic marker in kidney cancer. Their 2026 pooled review searches four data banks through October 2025 for studies tying the blood index to survival outcomes. Twenty-two studies qualified, covering local and advanced kidney cancer.
Higher index values predicted worse survival on every endpoint. Overall survival carried a pooled hazard ratio of 1.89 for high versus low values in the pooling. Progression-free and cancer-specific survival pointed the same way, with ratios of 1.74 and 1.63 in their figures. Region, cutoff choices, and disease stage explained much of the mismatch between studies. Robustness checks left the findings standing. The authors call the cheap blood index a strong independent predictor, while asking future work to fix one shared cutoff.
Catalog record
| CREATOR | Huan Zhang, Dan Yang, Liuyue Zeng, Weidong Wang, Zongxin Guo, Dan Liao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36023 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |