Tau beyond the Brain: Endoplasmic Reticulum Stress and Tau Phosphorylation as Emerging Drivers of Diabetic Nephropathy
Na-Yeong Kim, Chang-Myung Oh · 2026
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Description
Na-Yeong Kim and Chang-Myung Oh argue in a 2026 review that a brain protein may also drive diabetic kidney disease. That disease is the top cause of end-stage kidney failure worldwide and strikes a large share of people with diabetes. Current drugs slow it, yet many patients still progress to failure.
The protein is tau, long tied to Alzheimer disease and other brain disorders where it tangles inside neurons. Tau also turns up in the kidney and pancreas, at lower levels than in the brain. The authors discuss fresh evidence that added phosphate groups on tau, plus stress in the cell's protein-folding compartment, help injure the kidney's filters and tubules. If the link holds, it opens new drug targets for a disease that badly needs them.
Catalog record
| CREATOR | Na-Yeong Kim, Chang-Myung Oh |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 9 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |