Optimization of fat grafting to attenuate radiation damage: a narrative review
Amy Skarsfeldt, Katharina S. Berryman, Kento Takaya, Ivy J. Stejskal, Kellen Chen, Geoffrey C. Gurtner · 2026
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Description
Amy Skarsfeldt and co-authors review how grafting a patient's own fat can soften the damage left by radiation therapy. Radiation can stiffen tissue into fibrosis that worsens over time and spoils rebuilding surgery. Fat grafts seem to calm that process, but results vary and the best recipe is unsettled. Their 2026 narrative review gathers recent work on making grafts survive and work better.
Much effort goes into the stem cells inside fat, yet clinical use lags. Drug add-ons tested in mice helped grafts fight fibrosis, and a processed fat matrix product may serve patients who lack spare fat. The authors note that donor fat varies and is rarely analyzed in studies, a gap worth closing. Many enrichment steps would need factory-grade handling or off-label drugs, which burdens clinics. Uses for swelling, nerve pain, and wounds show early promise too.
Catalog record
| CREATOR | Amy Skarsfeldt, Katharina S. Berryman, Kento Takaya, Ivy J. Stejskal, Kellen Chen, Geoffrey C. Gurtner |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |