Metabolomic analysis of children with congenital heart disease complicated by neurological developmental abnormalities and CHD7 mutations
Xianghui Huang, Wanting Li, Ying Lin, Dan Li, Huiyue Zhang, Yuandan Chen, Wei Sheng, Deyi Zhuang · 2026
Read Metabolomic analysis of children with congenital heart disease complicated by neurological developmental abnormalities and CHD7 mutations by Xianghui Huang, Wanting Li, Ying Lin, Dan Li, Huiyue Zhang, Yuandan Chen, Wei Sheng, Deyi Zhuang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13561501.txt.
Description
Xianghui Huang and co-authors profile blood chemistry in children with heart and brain conditions in 2026. Some children born with a heart defect also show developmental delays, and a gene called CHD7 is sometimes mutated in them. Metabolic clues to that pairing were missing.
Seven such children were compared with heart-only patients and healthy peers. Serum profiles tended to separate the three groups. Candidate shifts clustered in steroid making and several vitamin and antioxidant paths. Two steroid-linked compounds appeared across comparisons. The authors flag them as possible markers and urge larger studies of the mechanism.
Catalog record
| CREATOR | Xianghui Huang, Wanting Li, Ying Lin, Dan Li, Huiyue Zhang, Yuandan Chen, Wei Sheng, Deyi Zhuang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |