External transportability of bacterial- and viral-associated host-response modules across public transcriptomic cohorts
Reuben S. Maghembe, Guichuan Lai, Benjamin Liu, Benjamin Liu · 2026
Read External transportability of bacterial- and viral-associated host-response modules across public transcriptomic cohorts by Reuben S. Maghembe, Guichuan Lai, Benjamin Liu, Benjamin Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13561310.txt.
Description
Reuben Maghembe tests whether gene-activity signatures for bacterial and viral infection hold up in new data, in a research paper from 2026. The signatures are sets of blood genes whose joint pattern points to one kind of infection. They were fixed in advance from one public data set, then applied unchanged to two others.
All five modules kept their expected direction in both outside cohorts, even across different measurement platforms. Four passed strict statistical checks in both. One bacterial module stayed borderline. Extensive stress tests, including deleting genes, barely moved the scores. Maghembe notes that keeping the right direction is not the same as uniform statistical strength.
Catalog record
| CREATOR | Reuben S. Maghembe, Guichuan Lai, Benjamin Liu, Benjamin Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 73 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |