Incidentally Diagnosed Very Well-Differentiated Gastric Adenocarcinoma at Intraoperative Frozen Section
Takuya Nagasaka, Hirofumi Rokutan, Akiko Komatsu, Nobuo Kanazawa, Tomio Arai · 2026
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Description
Takuya Nagasaka and co-authors report a stomach cancer found by accident in the middle of surgery for a different cancer. The patient, an 82-year-old man, was having part of his stomach removed for one adenocarcinoma when a frozen slice from the cut edge showed something unexpected: glands fused in irregular patterns. That odd architecture marked a second tumor, a very well-differentiated adenocarcinoma, a rare type whose cells look so normal that it is easily missed.
The surgeons widened the removal to secure clean margins. Later staining showed the new tumor's glands had lost a certain protein, ARID1A, while nearby healthy tissue kept it, confirming the diagnosis. The authors stress the lesson for pathologists: in frozen sections, shape can betray a cancer that cell appearance hides. Catching such subtle patterns during surgery, they argue, is what stands between a clean operation and a leftover tumor.
Catalog record
| CREATOR | Takuya Nagasaka, Hirofumi Rokutan, Akiko Komatsu, Nobuo Kanazawa, Tomio Arai |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 10 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |