Efficacy and safety of lorundrostat in uncontrolled hypertension: a systematic review, meta-analysis, and meta-regression
Sumet Kumar, Arshia Arif Janjua, Laksh Kumar, Sheikh Muhammad Ebtehaj Ali, Hanzlah Ahmed, Rayan Babar, Rumaisa Imtiaz Sheikh, Sana Mohammad Ali, Hadia Qazi, Fatima Hanif, Khizra Gul, Ayesha Sarwar Ali, Shehzadi Umme Rubab Bukhari, Adarsh Raja, Aayush Chaulagain · 2026
Read Efficacy and safety of lorundrostat in uncontrolled hypertension: a systematic review, meta-analysis, and meta-regression by Sumet Kumar, Arshia Arif Janjua, Laksh Kumar, Sheikh Muhammad Ebtehaj Ali, Hanzlah Ahmed, Rayan Babar, Rumaisa Imtiaz Sheikh, Sana Mohammad Ali, Hadia Qazi, Fatima Hanif, Khizra Gul, Ayesha Sarwar Ali, Shehzadi Umme Rubab Bukhari, Adarsh Raja, Aayush Chaulagain (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13561205.txt.
Description
Sumet Kumar and colleagues pooled trial evidence on lorundrostat, a new drug for high blood pressure that stays high despite several medicines. Lorundrostat blocks the making of aldosterone, a salt-holding hormone, while leaving related hormones alone.
Three trials with 1,568 patients compared the drug against placebo, a dummy treatment with no active drug. On average, systolic pressure fell about 8.4 points more on lorundrostat, and diastolic pressure fell about 3.8 points more. Side effects came more often on the drug, notably low pressure and high potassium, though serious harms were not clearly higher. Kumar says the drug looks promising but larger, longer trials must confirm its safety.
Catalog record
| CREATOR | Sumet Kumar, Arshia Arif Janjua, Laksh Kumar, Sheikh Muhammad Ebtehaj Ali, Hanzlah Ahmed, Rayan Babar, Rumaisa Imtiaz Sheikh, Sana Mohammad Ali, Hadia Qazi, Fatima Hanif, Khizra Gul, Ayesha Sarwar Ali, Shehzadi Umme Rubab Bukhari, Adarsh Raja, Aayush Chaulagain |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |