Juanbi Tang Attenuates Intervertebral Disc Degeneration by Suppressing p38MAPK/NF‐κB Signaling and Activating Atg5‐Dependent Autophagy to Promote Macrophage M2 Polarization: In Vivo and In Vitro Evidence
Ye‐Hui Wang, Wei Hou, Guo‐Sheng Tang, Xuan‐Geng Deng, Si‐Mao Song, Wei Cui, Yang Ye, Yang Yu · 2026
Read Juanbi Tang Attenuates Intervertebral Disc Degeneration by Suppressing p38MAPK/NF‐κB Signaling and Activating Atg5‐Dependent Autophagy to Promote Macrophage M2 Polarization: In Vivo and In Vitro Evidence by Ye‐Hui Wang, Wei Hou, Guo‐Sheng Tang, Xuan‐Geng Deng, Si‐Mao Song, Wei Cui, Yang Ye, Yang Yu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13560788.txt.
Description
Ye-Hui Wang and co-authors test a classic herbal formula against disc degeneration in this 2026 paper. Juanbi Tang has treated painful obstruction syndromes since 1732. Disc decay involves inflammation run by immune cells called macrophages. The formula chemistry was checked by fingerprint methods against pharmacopeia standards.
Rat discs injured by needle puncture modeled the disease. Imaging and tissue checks tracked degeneration across five groups. A blocker group tested whether cell self cleaning, called autophagy, carries the benefit. The formula calmed an inflammatory signaling route while boosting that cleanup. Immune cells shifted toward the healing type under treatment. Traditional formulas gain credibility when their mechanism survives controlled tests like this.
Catalog record
| CREATOR | Ye‐Hui Wang, Wei Hou, Guo‐Sheng Tang, Xuan‐Geng Deng, Si‐Mao Song, Wei Cui, Yang Ye, Yang Yu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |